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Cartoon illustrating the Calcigender paradigm as formulated by De Loof [2]. It says that it is a general principle in the Animal Kingdom that the Ca2+-homeostasis system displays substantial differences between males and females. Females extrude more Ca2+ than males do, a process in which sex steroids play an important role. Not only an 44+XX and 44+XY chromosomal configuration like in humans, but a variety of other sex-determining systems in other animals all yield such sex-related differential Ca2+-homeostasis, invariably with females extruding more Ca2+ through their reproduction-related activities than males. Because they are lipophilic, steroid sex hormones enter the membrane system of all cell types. They have effects on the Ca2+ system of all cells and tissues, the brain inclusive. The differences in green colour are only meant to indicate that there are differences in the complex whole Ca2+-homeostasis system, not to represent quantitative differences only. Indeed [Ca2+]i is very variable, e.g. due to short-lived Ca2+-puffs [3].
There is no generally accepted definition of gender, because the concept itself is not static but dynamic [20]. According to Weed [21] the meaning of gender depends on who uses the word, in what context, and for what ends. A few examples of definitions as used in medicine or in the humanities, in particular in sociology are:
Cartoon illustrating the idea that the main difference between the various gender forms resides in the Ca2+-homeostasis system, in particular that present in some brain areas. Given that the human brain contains about 100 billion nerve cells, it is de facto impossible that two individuals have exactly the same Ca2+-homeostasis system in the totality of their brain, even if these two individuals are identical twins. This figure illustrates the commonly observed situation that the sexual thinking and behaviour of transgenders reflects more the situation of the other heterosexual somatic sex than their own somatic genetic sex. Between these two depicted extremes, numerous intermediate forms are theoretically possible. Indeed, it is more likely that not the whole brain but specific brain regions can display (subtle) changes in Ca2+ homeostasis with effects on behaviour as a result.
From the study of comparative physiology of reproduction in vertebrates and invertebrates, it has become clear that many aspects of reproduction involving (hetero) gametes came into existence long ago in evolution, and that they have been very well conserved since [7]. For biologists this means that gender as a biological concept not only has a meaning for our own species Homo sapiens with its complex social organization, but for numerous other animal species as well. It also means that there must exist an evolutionarily well conserved genetics-based system that codes for key aspects of reproductive behaviour. The link between genetics and sex hormones is documented since long. In this paper, I emphasized the importance for gender in general, and for reproduction-linked behaviour in particular of the Ca2+-homeostasis system which is also largely genetics-based. This system is very versatile and dynamic. Due to the frequent occurrence of Ca2+-puffs (which are usually very short-lived) in many cell types and in particular in muscle cells, it is not easy to determine the exact [Ca2+]i in such cells. Hence my statement that all cells of a differentiated organism differ from each other, is not based upon exact measurements. It is deduced from a theoretical statistics-based argument, namely far too many causal agents play a role.
I can imagine that without a knowledgeable insight into the fundamentals of animal physiology and development, the hypothesis that sexual reproduction results from an evolutionarily ancient sort of prokaryotic (bacterial) infection of a proto-eukaryotic cell that eventually became the common ancestor of all eukaryotes, is at first encounter perceived as both counterintuitive and far-sought. Yet there are sound scientific arguments to support this view [7]. Not only is the reproductive state a disease state, it is not even a mild one, but a death-causing state: Sex kills is one of the numerous theories explaining aging phenomena [55]. In addition, the view that the female body, the brain inclusive, is somewhat more poisoned by Ca2+ than the male one [2] may sound discriminatory towards females in general, but it is not, to the contrary. The explanation is that the beneficial effects Ca2+ undoubtedly has in the body result from the fact that short-lived rising Ca2+ concentrations ( = toxic puffs) are causal to them, e.g. in biochemical signalling (Ca2+ as secondary messenger). As an example, in many species, females live longer than males, despite, or better thanks to the toxicity of Ca2+. Females have better means to remove excess Ca2+ from their body, and can therefore better cope with the toxicity of Ca2+. Yet, decalcification of the skeleton resulting in osteoporosis that affects woman more than man is a negative aspect.
The interplay between genetics, sex hormones, Ca2+-homeostasis, the social environment and other aspects of Nurture enables a huge variability in gender variants. In this context, a major gender-related topic of discussion is the place of homosexuality in an animal population, and the way this is perceived in human society in particular. It is known since long that homosexuality, one of the many possible gender variants, occurs in several animal species. For biologists this illustrates that this gender form must have a physiological basis that occurs widely in the animal kingdom, and that can generate variability in reproduction-related behaviour. The key actors in Ca2+-homeostasis are proteins that reside in membranes: Ca2+ channels and Ca2+-pumps. Bao and Swaab (2013) attribute little weight to the role of post-partum Nurture in steering the coming into existence of gender orientation, e.g. hetero- versus homosexuality. I support this view: Nature, thus genetics, is much more important than Nurture in defining gender and gender orientation. Differential sex steroid production and differential Ca2+-homeostasis are already effective long before birth.
In this game you'll find yourself on the different space locations, meeting and fucking with different intergalactic creatures. Your main task is to get in touch with lots of new races and become friends with them. But better lets be more then friends. Game contains in-game purchases but free stuff is enough to enjoy the game.
Chase after the sexiest schoolgirls this side of the multiverse and fuck your way to victory! All the stands between humanity and total destruction is your team of sexy hotties! Get ready for some really hot, uncensored content - Lead them into battle, and enjoy your rewards, by unlocking sex scenes with each of them! Play Free Now!
A great RPG fantasy game where you'll play as the half goblin who has been thrown out from his kingdom. Now he has found some new allies and your task is to help him to get back his reputation. To do that first you'll become a human and then you will start yo build your way to the power.
This game tells us the story after a big cataclysm that happened and mixed two different worlds together. In the result there are two main races - humans and beasts who look like humans. You'll play as a young guy who's name is Miles. Meet with hot girls and fight with wild animals on your adventure.
A game from Kazuki-Chan. A great creation with lots of images, animations and stories. The story about demons, dark lords and other evil creatures who come to the human world to complete their tasks. The game is divided in multiple chapters. Follow the in-game instructions and read the dialogs.
You will play as Ryen. He's something between human and dragon. Somehow life turns around in a way he becomes a king and now he'll have to deal with all tasks that kings have to. As usual in RPG Maker games you'll have to run around the maps and read the briefings to know where to search for the next task. Lots of hot images in this game.
This is something rare and that you've not probably not seen. Big giant girls are living a great life and they are protected and satisfied by normal humans that are penetrating and entering their pussies and other holes and entire bodies just to not get killed. Anyway, enjoy intros from the author.
In this game which is something like a dating simulator you'll have to spend your time at the Furry Beach Club. Explore this resort, meet lots of furry characters and try to get laid with them. The game contains some in-game purchases but you are able to unlock most of those features which require coins for free.
You play as Angelica, 18 years old good girl who studies really well, loves adventures and games, a typical schoolgirl. But there's one exception. Since childhood she found predisposition for sorcery. That's why she was taken to school of witches. Otherwise untrained sorcerers with magical powers are dangerous. I hope that this game will not freeze, as it contained one video that I couldn't reach.
In this sci-fi game you'll have to find lost scouts who were looking for a new planets for human colonization. Three worlds were picked and now contacts with all crews are lost. Find them, also try to find the best new home and try to find some common language with aliens you'll meet.
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